Antimalarial drug discovery: where next?
نویسندگان
چکیده
منابع مشابه
Antimalarial drug discovery: old and new approaches.
New drugs against malaria are greatly needed. Many approaches to antimalarial drug discovery are available. These approaches must take into account specific concerns, in particular the requirement for very inexpensive and simple to use new therapies and the need to limit the cost of drug discovery. Among important efforts that are currently ongoing are the optimization of therapy with available...
متن کاملAntimalarial drug discovery – the path towards eradication
Malaria is a disease that still affects a significant proportion of the global human population. Whilst advances have been made in lowering the numbers of cases and deaths, it is clear that a strategy based solely on disease control year on year, without reducing transmission and ultimately eradicating the parasite, is unsustainable. This article highlights the current mainstay treatments along...
متن کاملAntimalarial drug discovery: targeting protein kinases.
Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cancer and neurodegenerative pathologies. The characterisation of the kinome of the human malaria parasite Plasmodium falciparum has revealed profound divergences, at several levels, between PKs of the parasite and those of its host. Here, the authors review the major issues and recent advances regard...
متن کاملText Mining - Next Steps For Drug Discovery
The text mining community has shown significant impact for use of text mining in drug discovery and basic research. So far, there have been a lot of point solutions that have solved a particular problem or augmented a valuable database. The next step is integrating text mining as part of the entire literature analytic solution and delivering it effectively and comprehensively to support researc...
متن کاملDrug discovery in the next millennium.
Selection and validation of novel molecular targets have become of paramount importance in light of the plethora of new potential therapeutic drug targets that have emerged from human gene sequencing. In response to this revolution within the pharmaceutical industry, the development of high-throughput methods in both biology and chemistry has been necessitated. This review addresses these techn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2012
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.12.189